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Indication and Important Safety Information
What is DAYBUE or DAYBUE STIX (trofinetide)?
DAYBUE or DAYBUE STIX are prescription medicines used to treat Rett syndrome in adults and children 2 years of age and older. It is not known if DAYBUE or DAYBUE STIX is safe and effective in children under 2 years of age.
What are the possible side effects of DAYBUE or DAYBUE STIX?
Diarrhea: Diarrhea is a common side effect of DAYBUE or DAYBUE STIX that can sometimes be severe. Diarrhea may cause you to lose too much water from your body (dehydration). Before starting treatment with DAYBUE or DAYBUE STIX, stop taking laxatives. Tell your healthcare provider if you have diarrhea while taking DAYBUE or DAYBUE STIX. Your healthcare provider may ask you to increase the amount you drink or take antidiarrheal medicine as needed.
Vomiting: Vomiting is a common side effect of DAYBUE or DAYBUE STIX. Sometimes vomit can get into your lungs (aspiration), which could cause an infection (aspiration pneumonia). Tell your healthcare provider if you have severe vomiting or if vomiting happens often.
Weight loss: DAYBUE or DAYBUE STIX can cause weight loss. Tell your healthcare provider if you notice you are losing weight at any time during treatment with DAYBUE or DAYBUE STIX.
The most common side effects of DAYBUE or DAYBUE STIX include diarrhea and vomiting. Other side effects include fever, seizure, anxiety, decreased appetite, tiredness, and the common cold. These are not all the possible side effects of DAYBUE or DAYBUE STIX. Tell your healthcare provider if you have any side effects that bother you or do not go away.
What should I tell my healthcare provider before taking DAYBUE or DAYBUE STIX?
Before taking DAYBUE or DAYBUE STIX, tell your healthcare provider about all of your medical conditions, including if you:
have kidney problems.
are pregnant or plan to become pregnant. It is not known if DAYBUE or DAYBUE STIX will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if DAYBUE or DAYBUE STIX passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking DAYBUE or DAYBUE STIX.
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DAYBUE or DAYBUE STIX with certain medicines may affect how the other medicines work and can cause serious side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You can also call Acadia Pharmaceuticals Inc. at 1-844-4ACADIA (1-844-422-2342).
DAYBUE is available as an oral solution (200 mg/mL).
DAYBUE STIX for oral solution powder is available in 5,000 mg, 6,000 mg, and 8,000 mg packets.
The risk information provided here is not comprehensive. To learn more, talk with your healthcare provider and read the full Prescribing Information, including Patient Information, also available at DAYBUE.com.
Indication and Important Safety Information
What is DAYBUE or DAYBUE STIX (trofinetide)?
DAYBUE or DAYBUE STIX are prescription medicines used to treat Rett syndrome in adults and children 2 years of age and older. It is not known if DAYBUE or DAYBUE STIX is safe and effective in children under 2 years of age.
What are the possible side effects of DAYBUE or DAYBUE STIX?
Diarrhea: Diarrhea is a common side effect of DAYBUE or DAYBUE STIX that can sometimes be severe. Diarrhea may cause you to lose too much water from your body (dehydration). Before starting treatment with DAYBUE or DAYBUE STIX, stop taking laxatives. Tell your healthcare provider if you have diarrhea while taking DAYBUE or DAYBUE STIX. Your healthcare provider may ask you to increase the amount you drink or take antidiarrheal medicine as needed.
Vomiting: Vomiting is a common side effect of DAYBUE or DAYBUE STIX. Sometimes vomit can get into your lungs (aspiration), which could cause an infection (aspiration pneumonia). Tell your healthcare provider if you have severe vomiting or if vomiting happens often.
Weight loss: DAYBUE or DAYBUE STIX can cause weight loss. Tell your healthcare provider if you notice you are losing weight at any time during treatment with DAYBUE or DAYBUE STIX.
The most common side effects of DAYBUE or DAYBUE STIX include diarrhea and vomiting. Other side effects include fever, seizure, anxiety, decreased appetite, tiredness, and the common cold. These are not all the possible side effects of DAYBUE or DAYBUE STIX. Tell your healthcare provider if you have any side effects that bother you or do not go away.
What should I tell my healthcare provider before taking DAYBUE or DAYBUE STIX?
Before taking DAYBUE or DAYBUE STIX, tell your healthcare provider about all of your medical conditions, including if you:
have kidney problems.
are pregnant or plan to become pregnant. It is not known if DAYBUE or DAYBUE STIX will harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if DAYBUE or DAYBUE STIX passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking DAYBUE or DAYBUE STIX.
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking DAYBUE or DAYBUE STIX with certain medicines may affect how the other medicines work and can cause serious side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You can also call Acadia Pharmaceuticals Inc. at 1-844-4ACADIA (1-844-422-2342).
DAYBUE is available as an oral solution (200 mg/mL).
DAYBUE STIX for oral solution powder is available in 5,000 mg, 6,000 mg, and 8,000 mg packets.
The risk information provided here is not comprehensive. To learn more, talk with your healthcare provider and read the full Prescribing Information, including Patient Information, also available at DAYBUE.com.
WE'RE MIXING IT UP!
Introducing DAYBUE STIX—a new formulation of DAYBUE.
Coming spring 2026
Connect with an EducatorSee Patient Information